منابع مشابه
The role of hepatocytes and oval cells in liver regeneration and repopulation
The liver has the unique capacity to regulate its growth and mass. In rodents and humans, it grows rapidly after resection of more than 50% of its mass. This growth process, as well as that following acute chemical injury is known as liver regeneration, although growth takes place by compensatory hyperplasia rather than true regeneration. In addition to hepatocytes and non-parenchymal cells, th...
متن کامل[Platelets and liver regeneration].
Platelets are the smallest structures in circulating blood and have a convex disc construction with an equatorial diameter of 2-3 microns and have no nucleus. They are derived from megakaryocytes in the bone marrow. Following their normal life span of 8-10 days, they are removed from the circulation when passing through the spleen. Platelets have three types of secretory granules, i.e., alpha-g...
متن کاملLiver sinusoidal endothelial cells and liver regeneration.
Liver sinusoidal endothelial cells (LSECs) have long been noted to contribute to liver regeneration after liver injury. In normal liver, the major cellular source of HGF is the hepatic stellate cell, but after liver injury, HGF expression has been thought to increase markedly in proliferating LSECs. However, emerging data suggest that even after injury, LSEC expression of HGF does not increase ...
متن کاملLiver regeneration after liver transplantation.
BACKGROUND/PURPOSE The liver has a remarkable capacity to regenerate after injury or resection. The aim of this review is to outline the mechanisms and factors affecting liver regeneration after liver transplantation. METHODS Relevant studies were reviewed using Medline, PubMed and Springer databases. RESULTS A variety of cytokines (such as interleukin-6 and tumor necrosis factor-α), growth...
متن کاملTherapeutic liver repopulation in a mouse model of hypercholesterolemia.
Liver repopulation constitutes an attractive approach for the treatment of liver disorders or of diseases requiring abundant secretion of an active protein. We have described previously a model of selective repopulation of a normal liver by Fas/CD95-resistant hepatocytes, in which we achieved up to 16% hepatocyte repopulation. In the present study, we investigated the therapeutic efficacy of th...
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ژورنال
عنوان ژورنال: Current Opinion in Organ Transplantation
سال: 2013
ISSN: 1087-2418
DOI: 10.1097/mot.0b013e32835f07e2